We consider a non-conservative nonlinear Schrodinger equation (NCNLS) with time-dependent coefficients, inspired by a water waves problem. This problem does not have mass or energy conservation, but instead mass and energy change in time under explicit balance laws. In this paper we extend to the particular NCNLS two numerical schemes which are known to conserve energy and mass in the discrete level for the cubic NLS. Both schemes are second oder accurate in time, and we prove that their extensions satisfy discrete versions of the mass and energy balance laws for the NCNLS. The first scheme is a relaxation scheme that is linearly implicit. The other scheme is a modified Delfour-Fortin-Payre scheme and it is fully implicit. Numerical results show that both schemes capture robustly the correct values of mass and energy, even in strongly non-conservative problems. We finally compare the two numerical schemes and discuss their performance.