DOI: 10.1101/2023.05.24.542081

Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development

T.Yue Y. Guo X. Qi W. Zheng H. Zhang B. Wang B. Zhou X. Zeng Ouzhuluobu Y. He B. Su

T.Yue Y. Guo X. Qi ...+7 B. Su

摘要

Compared with lowlander migrants, native Tibetans have a higher reproductive success at high altitude though the underlying mechanism remains unclear. Here, we compared the transcriptome and histology of full-term placentas between native Tibetans and Han migrants. We found that the placental trophoblast shows the largest expression divergence between Tibetans and Han, and Tibetans show decreased immune response and endoplasmic reticulum stress. Remarkably, we detected a sex-biased expression divergence, where the male-infant placentas show a greater between-population difference than the female-infant placentas. The umbilical cord plays a key role in the sex-biased expression divergence, which is associated with the higher birth weight of the male newborns of Tibetans. We also identified adaptive histological changes in the male-infant placentas of Tibetans, including a larger umbilical cord vein area and wall thickness, and fewer syncytial knots. These findings provide valuable insights into the sex-biased adaptation of human populations, with significant implications for medical and genetic studies of human reproduction.

展开全部

图表提取

论文十问

参考文献

被引用

提问与回答

暂无人提供速读十问回答

被引用

笔记

问答