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DOI: 10.1101/2023.05.23.541952

A single cell transcriptomic fingerprint of stressed premature, imbalanced differentiation of embryonic stem cells.

X.Ruden A. Singh T. Marben ...+5 D. Rappolee
摘要
Sorbitol overrides pluripotency in two ESC lines as reported by bulk and scRNAseq, analyzed by UMAP. UMAP analyzed the effects of 5 stimuli - three stressed (200-300mM sorbitol with leukemia inhibitory factor +LIF) and two unstressed (+LIF, normal stemness -NS and -LIF, normal differentiation -ND). Sorbitol and RA decrease naive pluripotency and increase subpopulations of 2-cell embryo-like and XEN sub-lineages; primitive, parietal, and visceral endoderm (VE).
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