[PDF] Correspondence between Signaling and Developmental Patterns by Competing Cells: A Computational Perspective-论文阅读讨论-ReadPaper

摘要

Arrangement of variant phenotypes in ordered spatial assemblies during division of stem cells is essential for the selforganization of cell tissues. The cellular patterns of phenotypes competing for space and resources against one another are mostly driven by secreted diffusible chemical signaling clues. This complex process is carried out within a chronological framework of interplaying intracellular and intercellular events. This includes receiving external stimulants- whether secreted by other individuals or provided by the environment interpreting these environmental signals and incorporating the information to designate cell fate. An enhanced understanding of the building blocks of this framework would be of help to set the scene for promising regenerative therapies. In this study, by proposing a designative computational map, we show that there is a correspondence between signaling and developmental patterns that are produced by competing cells. That is, the model provides an appropriate prediction for the final structure of the differentiated cells in a competitive environment. Besides, given that the final state of the cellular organization is known, the corresponding regressive signaling patterns are partly predictable following the proposed map.

展开全部

图表提取

论文十问

参考文献

被引用

提问与回答

暂无人提供速读十问回答