DOI: 10.1101/2023.05.22.23290180

40HZ photoacoustic interventions combined with blue light improve brain function and sleep quality in a healthy population

X.Xu Z. Gong K. Jin P. Huang C. Zhou Q. Zeng J. Teng Z. Liu H. Zhang Q. Xu Y. Chen C. Fang M. Zhang

X.Xu Z. Gong K. Jin ...+9 M. Zhang

摘要

Recent studies suggest that 40Hz photoacoustic stimulation is beneficial for improving cognition, and is safe and effective in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). It has been reported that the healthy population responds more strongly to the 40 Hz intervention compared to MCI and AD patients. Therefore, the aim of this study was to explore the effectiveness of 40 Hz photoacoustics in preventing cognitive impairment and improving sleep quality in the healthy population. Four weeks of 40 Hz intervention significantly improved sleep quality (PSQI) (p=0.028) and enhanced functional connectivity in the hippocampus and default mode network (DMN) (in the cognitively impaired population, functional connectivity showed a decreasing trend). These results were consistent with findings from the FDA clinical trial on MCI/AD patients that showed enhanced connectivity of the core regions PCC and mPFC within the DMN network. No serious adverse effects were reported throughout the intervention. This study is the first to validate the efficacy and safety of a 40 Hz photoacoustic intervention in a healthy population, suggesting its potential in preventing cognitive decline in a healthy population.

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