This website requires JavaScript.
DOI: 10.1101/2023.05.22.541218

Saxitoxin potentiates Zika virus-induced cell death in human neurons but not in neural progenitors and astrocytes

L. R. Q.Souza C. D. S. G. Pedrosa T. P. Pijuan ...+5 S. K. Rehen
摘要
The Zika virus (ZIKV) outbreak in Brazil between 2015 and 2016 was associated with an increased prevalence of severe congenital malformations, including microcephaly. Notably, the distribution of microcephaly cases was not uniform across the country, with a disproportionately higher incidence recorded in the Northeast region (NE). Our previous work demonstrated that saxitoxin (STX), a toxin ubiquitously present in the drinking water reservoirs of the NE, exacerbated the damaging effects of ZIKV on the developing brain. In the present study, we hypothesized that STX's impact might vary among different neural cell types. Our experimental observations suggest that exposure to STX potentiates the neurotoxic effect of Zika Virus (ZIKV) on human neuronal cells. However, while ZIKV infection demonstrated severe impacts on astrocytes and neural stem cells (NSCs), the addition of STX did not exacerbate these effects. We observed that neurons subjected to STX exposure were more prone to apoptosis and displayed a higher number of ZIKV-infected cells. These findings suggest that STX exacerbates the harmful effects of ZIKV on neurons, thereby providing a plausible explanation for the heightened severity of ZIKV-induced congenital malformations observed in Brazil's NE. This study underscores the importance of understanding the interactive effects of environmental toxins and infectious pathogens on neural development, with potential implications for public health policies and interventions.
展开全部
图表提取

暂无人提供速读十问回答

论文十问由沈向洋博士提出，鼓励大家带着这十个问题去阅读论文，用有用的信息构建认知模型。写出自己的十问回答，还有机会在当前页面展示哦。

Q1论文试图解决什么问题？
Q2这是否是一个新的问题？
Q3这篇文章要验证一个什么科学假设？
0
被引用
0
笔记
0
问答