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Quantum correlation light-field microscope with extreme depth of field

Dec 2022

Light-field microscopy (LFM) is a 3D microscopy technique whereby volumetricinformation of a sample is gained in a single shot by simultaneously capturingboth position and angular information of light emanating from a sample.Conventional LFM designs require a trade-off between position and angularresolution, requiring one to sacrifice resolving power for increased depth offield (DOF) or vice versa. In this work, we demonstrate a LFM design that doesnot require this trade-off by utilizing the inherent strong correlation betweenspatial-temporal entangled photon pairs. Here, one photon from the pair is usedto illuminate a sample from which the position information of the photon iscaptured directly by a camera. By virtue of the strong momentum/angularanti-correlation between the two photons, the angular information of theillumination photon can then be inferred by measuring the angle of itsentangled partner on a different camera. We demonstrate that a resolving powerof 5$\mu$m can be maintained with a DOF of $\sim500$$\mu$m, over an order ofmagnitude larger compared to conventional LFM designs. In the extreme, at aresolving power of 100$\mu$m, it is possible to achieve near infinite DOF

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