This website requires JavaScript.
DOI: 10.1101/2022.12.23.22283910

Striatal Dopaminergic Asymmetry as a marker of Brain-First and Body-First Subtypes in de novo Parkinson's Disease

J. M.Boertien M. Nazmuddin J. Kłos ...+3 T. Van Laar
摘要
Recently, the -Synuclein Origin and Connectome (SOC) model of Parkinson's disease (PD) has been proposed, which predicts a more malignant clinical subtype and symmetrical neurodegeneration in body-first compared to brain-first PD. Here, motor symptoms (MDS-UPDRS III), non-motor symptoms (NMSQ) and T1 MRI data of an incident de novo PD cohort, were compared between PD subjects with levels of putaminal dopaminergic asymmetry in the lowest tertile (PD-sym, n=41) and highest tertile (PD-asym, n=41), as measured by FDOPA-PET. PD-sym was associated with a higher burden of motor symptoms and non-motor symptoms with a probable neurological substrate caudally from the substantia nigra. Though overall brain volume was lower in PD-sym, no differences in the volumes and asymmetricity of specific brain regions could be found between PD-sym and PD-asym after adjusting for multiple testing. The more malignant clinical picture suggests an overrepresentation of body-first PD subjects in PD-sym according to the SOC-model. Also, lower overall brain volumes were found in PD-sym. However, structural MRI data might not be sufficient to assess regional differential degeneration between PD-sym and PD-asym in de novo PD. Additional imaging modalities and longitudinal follow-up could be required to support or reject the SOC-model.
展开全部

暂无人提供速读十问回答

论文十问由沈向洋博士提出,鼓励大家带着这十个问题去阅读论文,用有用的信息构建认知模型。写出自己的十问回答,还有机会在当前页面展示哦。

Q1论文试图解决什么问题?
Q2这是否是一个新的问题?
Q3这篇文章要验证一个什么科学假设?
0
被引用
笔记
问答